Receptors

George Richerson

George B. Richerson, MD, PhD

Title/Position
Professor
Head, Neurology
We are studying the role of serotonin neurons in mediating the effects of acidosis on brain function and behavior. We have shown that serotonin neurons are exquisitely sensitive to changes in pH. They are close to large arteries in the brain and contribute to the increase in breathing induced by...
Marcinkiewcz, Catherine

Catherine Marcinkiewcz, PhD

Title/Position
Assistant Professor
Serotonin neurons are mainly localized to the raphe nuclei of the brainstem, but their axons are widely distributed throughout the nervous system and have a ubiquitous role in physiological processes and behavior. Adding to this complexity is the diverse array of high-affinity receptors that bind...
Gordon Buchanan

Gordon Buchanan, MD, PhD

Title/Position
Associate Professor
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with intractable epilepsy, but specific mechanisms of how a seizure can cause death are poorly understood. Research efforts in my laboratory are focused on using animal models to understand the mechanisms by which...
FrankCA

C. Andrew Frank, PhD

Title/Position
Associate Professor
Homeostasis is a robust form of regulation that allows a system to maintain a constant output despite external perturbations. In the nervous system, homeostasis plays a critical role in regulating neuronal and synaptic activity. Yet the molecular basis of this form of neural plasticity is generally...
RussoA

Andrew F. Russo, PhD

Title/Position
Professor
My research interest is the molecular basis of migraine. A hallmark of migraine is altered sensory perception coupled with head pain. To understand the mechanisms underlying these events, we have focused on the neuropeptide calcitonin gene-related peptide (CGRP), whose levels are elevated during...
Bassuk-Alexander

Alexander Bassuk, MD, PhD

Title/Position
Professor & Chair
Dr. Alex Bassuk is a Professor and Chair of Pediatrics, and holds the Joel and Jay Stead Chair for Leadership in Children's Medicine, and is Physician-in-Chief for University of Iowa Stead Family Children's Hospital. Dr. Bassuk is a member of the University of Iowa Graduate Programs in Genetics...
KayA

Alan R. Kay, PhD

Title/Position
Professor
A high concentration of free ionic zinc in synaptic vesicles is a prominent feature of some of the excitatory pathways in the mammalian forebrain. Despite the wealth of information on its distribution, and role in metalloenzymes and proteins, the role of vesicular zinc remains enigmatic, and serves...
Huxing Cui

Huxing Cui, PhD

Title/Position
Assistant Professor
We study the neural circuits and intraneuronal signaling mechanisms that regulate appetite, body weight, sleep, and cardiorespiratory function in mice and aim to understand how these regulatory processes go awry in metabolic disorders. To this end, we employee state-of-the-art neuroscience...
SabharwalRasna

Rasna Sabharwal, PhD

Title/Position
Assistant Professor
My research focuses on elucidating central brain mechanisms underlying Alzheimer’s disease, psychosocial disorders, heart failure and sudden cardiac death. The lab uses multidisciplinary approaches including radiotelemetry, optogenetics, neurophysiology, pharmacology, behavioral and molecular...
Joel Geerling

Joel C. Geerling, MD, PhD

Title/Position
Assistant Professor
In the lab, we use genetic techniques to isolate and manipulate neurons that mediate basic physiologic functions including sleep, appetite, bladder control, and thermoregulation. My focus lies in identifying and deciphering previously unknown connections between neurons in the brainstem and other...