Gordon Buchanan, MD, PhD

Associate Professor

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with intractable epilepsy, but specific mechanisms of how a seizure can cause death are poorly understood. Research efforts in my laboratory are focused on using animal models to understand the mechanisms by which a seizure can result in death. In particular we are interested in sleep state-dependent and circadian phase-dependent effects of seizures on cardiac and respiratory function and mortality. On-going research projects are aimed at understanding: normal sleep-wake regulation, mechanisms of stimulus-induced arousal from sleep, seizure susceptibility, seizure-related mortality, ictal and post-ictal cardiorespiratory function, circadian regulation and effects of sleep deprivation on seizure-related death. We employ a variety of techniques including: electroencephalographic (EEG), electromyographic (EMG), electrocardiographic (EKG) and depth electrode recordings, whole body breathing plethysmography, activity and body temperature telemetry, acute and chronic responsive sleep-deprivation, seizure/epilepsy induction techniques (maximal electroshock, amygdala kindling, pilocarpine-status epilepticus induced epileptogenesis), and reverse and forward microdialysis in live, chronically instrumented normal and transgenic mice.

Recent publications

Research areas
  • Cellular and molecular neuroscience
  • Systems neuroscience
  • Neurotransmitters
  • Receptors
  • Epilepsy/Seizures
  • Alzheimer's Disease
  • Neurodegenerative disorders
  • Sleep
  • Hippocampus
  • Amygdala
  • Thalamus
  • Brainstem
  • In vivo electrophysiology
  • Transgenic models
  • Animal behavior
  • Anatomical tracing
Gordon Buchanan

1332 PBDB
United States

Phone Number