The main focus of my research has been on response selection, the set of cognitive processes that enable us to transform sensory information into goal-directed actions. I have approached this topic from a variety of perspectives, including motor learning, bimanual coordination, and dual-task...

In patient with lewy body disease, the protein alpha-synuclein aggregates, leading to severe multi-system symptoms, including hallucinations, loss of smell, dementia, imbalance, fluctuating confusion, and anxiety/depression. The main research goal of the Aldridge Laboratory is to understand the...

My research focuses on the cortical mechanisms subserving human language and vocalization. Major goals of the research are to understand the representation of self-vocalization stimuli in primary and associated auditory cortices, elucidate and characterize the cortico-cortical interactions between...

We are interested in how humans carry out and maintain goal-directed behaviors and how the cognitive system resolves challenges to this goal. Common examples of such challenges are unexpected events and action errors. As part of this effort, we investigate the dynamic interplay between brain...

In the lab, we use genetic techniques to isolate and manipulate neurons that mediate basic physiologic functions including sleep, appetite, bladder control, and thermoregulation. My focus lies in identifying and deciphering previously unknown connections between neurons in the brainstem and other...

In general, Dr. Doorn's work involves examining the role of reactive intermediates in toxicity and disease. Specifically, his mechanistic, hypothesis-driven research focuses on the potential role of protein modification by a reactive metabolite of dopamine metabolism in neurotoxicity and...

The lab has two main areas of interest, the biology of DEG/ENaC channels and cystic fibrosis. DEG/ENaC channels are a novel family of non-voltage gated cation channels, including ASIC1, -2, and -3 in mammals and the Pickpocket genes in Drosophila. In the peripheral nervous system, they may serve as...

The specific problem we are interested is cognitive dysfunction in Parkinsons disease. Our current research focuses on the influence of dopamine on prefrontal networks controlling cognitive behaviors such as timing and performance monitoring. We combine ensemble recording from populations of neurons...

My research interests are in human cognitive neuropsychology, with emphases in frontal lobe dysfunction, language processing, and cognitive/behavioral rehabilitation. The primary methods involve application of experimental cognitive and behavioral paradigms in patients with circumscribed brain...

My laboratory is interested in identifying and understanding the function of genes, which cause a variety of human disorders. Our research efforts have focused on the molecular genetics of monogenic disorders with focus on hereditary blindness including Bardet-Biedl Syndrome, retinitis pigmentosa...

Cellular protein misfolding leads to the occurrence of amyloid oligomers and protein aggregates inside the cell. Protein misfolding is the cause of cellular dysfunction associated with numerous diseases such as cardiomyopthy, Huntington’s disease, Alzheimer’s disease, adult onset diabetes, cancer...