My research focuses on three key knowledge gaps in hemophilia: 1) mechanisms leading to decreased brain volumes in hemophilia A, 2) defining the executive dysfunction and behavior changes in hemophilia A, and 3) neuroinflammatory biomarkers to predict changes in the brain. My research laboratory...

The Kliemann lab studies the neuroscience of human social behavior, from a basic research perspective, as well as in its applications to disorders (e.g., autism) and neurological populations (e.g., brain lesions). We are interested in the biological basis of cognition in the brain, especially how...

Research at the Development, Experience, and Neurocognition Lab addresses the long-standing question of why some children, often from disadvantaged backgrounds, fall behind their peers in academic achievement while others thrive. We take several major approaches to address this broad question. We...

The main focus of my research has been on response selection, the set of cognitive processes that enable us to transform sensory information into goal-directed actions. I have approached this topic from a variety of perspectives, including motor learning, bimanual coordination, and dual-task...

My research is about brain development in the context of medical illness, particularly childhood cancer. Key neuroscience tools I use include: neuroimaging, neuropsychological testing and experimental cognitive neuroscience tasks. I recently expanded my research to include neurochemical markers of...

My research is aimed at understanding brain-behavior relationships in humans, at systems level. Two main approaches are used: the lesion method, in which brain-damaged patients are studied with neuropsychological procedures to determine how certain lesion sites are related to certain cognitive and...

We are studying the role of serotonin neurons in mediating the effects of acidosis on brain function and behavior. We have shown that serotonin neurons are exquisitely sensitive to changes in pH. They are close to large arteries in the brain and contribute to the increase in breathing induced by...

In patient with lewy body disease, the protein alpha-synuclein aggregates, leading to severe multi-system symptoms, including hallucinations, loss of smell, dementia, imbalance, fluctuating confusion, and anxiety/depression. The main research goal of the Aldridge Laboratory is to understand the...

My research broadly concerns how people recover the meaning of spoken language as it unfolds in real-time, and in particular how they cope with the vast amount of variability in the speech signal. To this end, we use techniques like head-mounted eye-tracking, event-related potentials and inter...

Humans spend about a third of their life sleeping. Yet, our understanding of the cognitive, emotional and neurodevelopmental functions of this essential behavior and how these may be disrupted in clinical populations is still very limited. Sleep disturbances are observed in most major psychiatric...

A high concentration of free ionic zinc in synaptic vesicles is a prominent feature of some of the excitatory pathways in the mammalian forebrain. Despite the wealth of information on its distribution, and role in metalloenzymes and proteins, the role of vesicular zinc remains enigmatic, and serves...

Dr. Hoth is a board certified clinical neuropsychologist with expertise in aging and cognitive changes associated with chronic medical illnesses. She received her Ph.D. in Clinical Psychology from the University of Iowa and completed both her pre-doctoral internship and a two-year fellowship in...