My research focuses on three key knowledge gaps in hemophilia: 1) mechanisms leading to decreased brain volumes in hemophilia A, 2) defining the executive dysfunction and behavior changes in hemophilia A, and 3) neuroinflammatory biomarkers to predict changes in the brain. My research laboratory...

My research is aimed at understanding brain-behavior relationships in humans, at systems level. Two main approaches are used: the lesion method, in which brain-damaged patients are studied with neuropsychological procedures to determine how certain lesion sites are related to certain cognitive and...

We are studying the role of serotonin neurons in mediating the effects of acidosis on brain function and behavior. We have shown that serotonin neurons are exquisitely sensitive to changes in pH. They are close to large arteries in the brain and contribute to the increase in breathing induced by...

Serotonin neurons are mainly localized to the raphe nuclei of the brainstem, but their axons are widely distributed throughout the nervous system and have a ubiquitous role in physiological processes and behavior. Adding to this complexity is the diverse array of high-affinity receptors that bind...

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with intractable epilepsy, but specific mechanisms of how a seizure can cause death are poorly understood. Research efforts in my laboratory are focused on using animal models to understand the mechanisms by which...

The Psychiatry and Early Neurobiological Development Lab (PENDL) at the University of Iowa Carver College of Medicine seeks to understand molecular and cellular aspects of early brain development and their relevance to psychiatric disorders. Hanna Stevens, the PI, is particularly interested in...

Humans spend about a third of their life sleeping. Yet, our understanding of the cognitive, emotional and neurodevelopmental functions of this essential behavior and how these may be disrupted in clinical populations is still very limited. Sleep disturbances are observed in most major psychiatric...

My laboratory is interested in the effect of environmental pollutants, such as neurotoxic polychlorinated biphenyls (PCBs), and their transformation products on the developing brain. We use exposomics approaches to identify the metabolites formed in various model systems, including animal models...

My research focuses on elucidating central brain mechanisms underlying Alzheimer’s disease, psychosocial disorders, heart failure and sudden cardiac death. The lab uses multidisciplinary approaches including radiotelemetry, optogenetics, neurophysiology, pharmacology, behavioral and molecular...

We combine behavioral, physiological, functional neuroanatomical, and cellular approaches to unravel the neural circuitry that underlies adaptive neuroendocrine responses to stress. Recently we have identified a locus in the basal forebrain that serves as a neural hub for integrating and relaying...

Alcoholism, alcohol abuse, and the medical complications of excessive drinking are major world-wide health problems. There are three long-term goals of my laboratory: (1) Alcohol exposure during development results in fetal alcohol spectrum disorders (FASD) and induces profound damages to the...

The Jiang lab seeks to understand the cognitive and neural mechanisms that enable goal-directed behavior using a combination of lab- and web-based behavioral studies, functional neuroimaging, computational modeling and virtual reality technology. Specifically, the lab focuses on the fundamental...