My research focuses on three key knowledge gaps in hemophilia: 1) mechanisms leading to decreased brain volumes in hemophilia A, 2) defining the executive dysfunction and behavior changes in hemophilia A, and 3) neuroinflammatory biomarkers to predict changes in the brain. My research laboratory...

This laboratory is interested in the neuroanatomy, neurophysiology and neuropharmacology of the central nervous system (CNS) pathways that convey pain, as well as the bulbospinal pathways that mediate the production of analgesia. Our studies emphasize a systems-level approach in which many different...

Neurons extend long projections called axons that establish connections throughout the body. In humans, axons can reach over a meter in length and extreme isolation from the cell body imposes unique challenges on this compartment. Axonal degeneration is a prominent event in many neurodegenerative...

Research interests are directed toward the neural regulation of the circulation in pathologic states such as hypertension and heart failure. Specific studies examine the cellular and molecular mechanisms of mechanical activation of baroreceptor neurons and the role of mechanosensitive ion channels...

Dr. Benson's research interests include the study of ion channels involved in sensation. We have focused on a class of ion channels called Acid-sensing Ion Channels (ASICs), which play a role in responses to nociceptive, taste, and mechanical stimuli. We have discovered that ASICs are highly...

We are studying the role of serotonin neurons in mediating the effects of acidosis on brain function and behavior. We have shown that serotonin neurons are exquisitely sensitive to changes in pH. They are close to large arteries in the brain and contribute to the increase in breathing induced by...

Serotonin neurons are mainly localized to the raphe nuclei of the brainstem, but their axons are widely distributed throughout the nervous system and have a ubiquitous role in physiological processes and behavior. Adding to this complexity is the diverse array of high-affinity receptors that bind...

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with intractable epilepsy, but specific mechanisms of how a seizure can cause death are poorly understood. Research efforts in my laboratory are focused on using animal models to understand the mechanisms by which...

Homeostasis is a robust form of regulation that allows a system to maintain a constant output despite external perturbations. In the nervous system, homeostasis plays a critical role in regulating neuronal and synaptic activity. Yet the molecular basis of this form of neural plasticity is generally...

The Psychiatry and Early Neurobiological Development Lab (PENDL) at the University of Iowa Carver College of Medicine seeks to understand molecular and cellular aspects of early brain development and their relevance to psychiatric disorders. Hanna Stevens, the PI, is particularly interested in...

Mental illnesses such as anxiety disorder are very common but have always been challenging to study because most symptoms are subjective, qualitative, and can vary widely across different individuals. The brain is also more complex than many other organs because different regions of the brain can...

My research interest is the molecular basis of migraine. A hallmark of migraine is altered sensory perception coupled with head pain. To understand the mechanisms underlying these events, we have focused on the neuropeptide calcitonin gene-related peptide (CGRP), whose levels are elevated during...