Ion channels

chris-benson

Christopher Benson, MD

Title/Position
Professor
Dr. Benson's research interests include the study of ion channels involved in sensation. We have focused on a class of ion channels called Acid-sensing Ion Channels (ASICs), which play a role in responses to nociceptive, taste, and mechanical stimuli. We have discovered that ASICs are highly...
George Richerson

George B. Richerson, MD, PhD

Title/Position
Professor
Head, Neurology
We are studying the role of serotonin neurons in mediating the effects of acidosis on brain function and behavior. We have shown that serotonin neurons are exquisitely sensitive to changes in pH. They are close to large arteries in the brain and contribute to the increase in breathing induced by...
FrankCA

C. Andrew Frank, PhD

Title/Position
Associate Professor
Homeostasis is a robust form of regulation that allows a system to maintain a constant output despite external perturbations. In the nervous system, homeostasis plays a critical role in regulating neuronal and synaptic activity. Yet the molecular basis of this form of neural plasticity is generally...
ChanAubrey

Aubrey Chan, MD, PhD

Title/Position
Assistant Professor
Mental illnesses such as anxiety disorder are very common but have always been challenging to study because most symptoms are subjective, qualitative, and can vary widely across different individuals. The brain is also more complex than many other organs because different regions of the brain can...
Bassuk-Alexander

Alexander Bassuk, MD, PhD

Title/Position
Professor & Chair
Dr. Alex Bassuk is a Professor and Chair of Pediatrics, and holds the Joel and Jay Stead Chair for Leadership in Children's Medicine, and is Physician-in-Chief for University of Iowa Stead Family Children's Hospital. Dr. Bassuk is a member of the University of Iowa Graduate Programs in Genetics...
KayA

Alan R. Kay, PhD

Title/Position
Professor
A high concentration of free ionic zinc in synaptic vesicles is a prominent feature of some of the excitatory pathways in the mammalian forebrain. Despite the wealth of information on its distribution, and role in metalloenzymes and proteins, the role of vesicular zinc remains enigmatic, and serves...
williamsaislinn

Aislinn Williams, MD, PhD

Title/Position
Assistant Professor
The Williams Lab is interested in understanding the molecular and cellular mechanisms by which genetic risk factors contribute to psychiatric disease from a developmental perspective. Their current projects focus on voltage-gated calcium channel genes, which have been linked to the risk of...
John Wemmie

John Wemmie, MD, PhD

Title/Position
Professor
My lab uses genetic manipulation in mice to study the effects of Acid Sensing Ion Channels (ASICs) on behavior. Because one of these channels, ASIC1, is abundant in the amygdala complex, we tested whether it plays a role in Pavlovian fear conditioning. We found that ASIC1a knockout mice have reduced...
Kathleen Sluka

Kathleen A. Sluka, PT, PhD

Title/Position
Professor
Dr. Sluka's laboratory studies the peripheral and central mechanisms of chronic musculoskeletal pain. These studies primarily involve the use of animal models of muscle pain developed and characterized in Dr. Sluka's laboratory. Current projects are aimed at deciphering the role of descending...
Mark Niciu

Mark J. Niciu, MD, PhD

Title/Position
Assistant Professor
Our clinical and translational research group seeks to better understand the pathophysiology and therapeutics of major mood and substance use disorders including their comorbidity. A major focus has been the identification, replication, and dissemination of biomarkers of treatment response to the...