Mark W. Chapleau, PhD

Internal Medicine - Cardiology
Molecular Physiology & Biophysics

Dr. Chapleau's research focuses on neural mechanisms in cardiovascular regulation; with emphasis on baroreceptor mechanosensory transduction, modulation of excitability of baroreceptor and sympathetic neurons, and determinants of baroreflex sensitivity, arterial chemoreceptor reflex sensitivity and sympathovagal balance in health and disease. Studies explore mechanisms of dysregulation and use of novel therapeutic approaches (e.g., gene transfer, vagus nerve stimulation, exercise, electroacupuncture) in mouse models of hypertension, heart failure, hypertrophic cardiomyopathy and metabolic syndrome.

Recent publications

Research areas
  • Cellular and molecular neuroscience
  • Systems neuroscience
  • Autonomic neuroscience
  • Ion channels
  • Neurotransmitters
  • Receptors
  • Gene regulation
  • Hormones
  • Neuromuscular disorders
  • Cardiovascular disorders
  • Migraine
  • Peripheral Nervous System
  • Pain
  • Limbic System
  • Stress
  • Mechanotransduction
  • Neuroimaging
  • In vivo electrophysiology
  • Transgenic models
  • In vitro electrophysiology
  • Molecular biology
  • Cell culturing
Mark Chapleau

629 MRC
United States

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