Current Positions

• Professor of Internal Medicine-Cardiovascular Medicine
• Professor of Molecular Physiology and Biophysics

Education

• PhD, Physiology, Louisiana State University Medical Center, New Orleans, Louisiana
• Postdoctoral Fellow, University of Iowa College of Medicine, Iowa City, Iowa

Graduate Program Affiliations

• Neuroscience

Center, Program and Institute Affiliations

• Cardiovascular Research Center
• Fraternal Order of Eagles Diabetes Research Center

Research Interests

Dr. Chapleau's research focuses on mechanisms of autonomic regulation in health and disease including effects of aging, hypertension, hypercholesterolemia, cardiomyopathy, myocardial infarction (MI), heart failure, and muscular dystrophy. Key hypotheses involve the roles of acid-sensing ion channels in sensory transduction, reactive oxygen species and angiotensin in sensory and sympathetic signaling, and oxidative stress in autonomic dysregulation. Experimental approaches include assessment of the cellular and molecular basis of sensory transduction and neuronal excitability in baroreceptor and sympathetic neurons using patch-clamp, imaging, and molecular techniques; recording of baroreceptor and sympathetic nerve activity in vivo; and assessment of cardiovascular and autonomic function in conscious mice using radiotelemetry.