Ashley Plumb, PhD

Physical Therapy & Rehabilitation Sciences

Elucidating the role of testosterone in activity-induced muscle pain in male and female mice


Females experience higher prevalence of chronic pain which emerges around the time of puberty suggesting that sex hormones play a role. My laboratory developed an activity-induced musculoskeletal pain model that produces behavioral sex differences in which females develop bilateral pain while males develop unilateral pain. Previously, our laboratory determined that testosterone mediates the behavior phenotype. I am interested in understanding the specific pathways underlying testosterone’s contributions to nociceptive processing which may lead to novel and safer therapies for individuals suffering from chronic pain.

Ashley Plumb
Macomb, IL
BS, Psychology, St. Ambrose University