General research activities: My lab uses mouse models of human neurodegenerative disease to study basic pathophysiology and potential treatments, with a special focus on the polyglutamine family of neurodegenerative diseases. The major projects I have in the lab are 1) investigating the role of protein quality control in polyglutamine disease using mice engineered to lack portions of the protein quality control machinery and 2) investigating the role of protein aggregation and abnormal protein complex formation in polyglutamine disease pathogenesis.

Recent publications