- Brain Awareness Week
Neuronal cytoskeleton, signal transduction, and neurodegenerative diseases
Our laboratory studies tau protein, a microtubule associated protein that is also the primary component of the neurofibrillary tangles of Alzheimer's disease. A few years ago, we discovered that tau interacts with non-receptor src family tyrosine kinases. We are currently identifying and investigating new functions acquired by tau as a consequence of this interaction. Our hypothesis is that tau has a role in signal transduction in neurons. We are also investigating a possible role for this interaction in the neuropathogenesis of Alzheimer's disease and other age-related neurodegenerative diseases.