Robert Felder M.D.
robert-felderatuiowadotedu
Professor of Internal Medicine

My laboratory utilizes electrophysiological, immunohistochemical and molecular techniques to explore the contribution of the brain to cardoiovascular disease states. The primary focus is upon heart failure in rodent models, with an emphasis on forebrain influences of the pro-inflammatory cytokines and the renin-angiotensin-aldosterone system on volume regulation and sympathetic drive.

 

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Selected Publications

Kang, Y.M., Zhang, Z.H., Johnson, R.F., Yu, Y., Weiss, R.M., Beltz, T., Johnson, A.K., and Felder, R.B.: Novel Effect of Mineralocorticoid Receptor Antagonism to Reduce Pro-Inflammatory Cytokines and Hypothalamic Activation in Rats with Ischemia-induced Heart Failure.  Circ. Res., 99: 758-66, 2006.

Yu, Y., Kang, Y.M., Zhang, Z.H., Wei, S.G., Chu, Y., Weiss, R.M., and Felder, R.B:  Increased Cyclooxygenase-2 Expression in Hypothalamic Paraventricular Nucleus in Rats with Heart Failure: Role of Nuclear Factor κ B.  Hypertension, 49:511-518, 2007.

Yu, Y., Zhang, Z.H., Wei, S.G., Chu, Y., Weiss, R.M., Heistad, D.D., and Felder, R.B:   Central Gene Transfer of Interleukin-10 Reduces Hypothalamic Inflammation and Evidence of Heart Failure in Rats after Myocardial Infarction (Subject of Editorial Comment).  Circ. Res., 101:304-312, 2007.

Yu, Y., Wei, S.G, Zhang, Z.H., Gomez-Sanchez, E.P., Weiss, R.M., and Felder, R.B.: Does Aldosterone Upregulate the Brain Renin-Angiotensin System in Rats with Heart Failure (Subject of Editorial Comment).   Hypertension, 51:727-733, 2008.

Wei, S.G., Yu, Y., Zhang, Z.H., Weiss, R.M., and Felder, R.B.:  Angiotensin II Triggered p44/42 Mitogen-Activated Protein Kinase Mediates Sympathetic Excitation in Heart Failure Rats.  Hypertension, 52:342-350, 2008.

Kang, Y.M., Zhang, Z.H., Xue, B., Weiss, R.M., and Felder, R.B:  Inhibition of Brain Pro- inflammatory Cytokine Synthesis Reduces Hypothalamic Excitation in Rats with Ischemia-Induced Heart Failure.   Am. J. Physiol., 295:H227-H236, 2008