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Research in our laboratory utilizes dynamic imaging in live brain tissue slices to study the development and remodeling of neurons and glia in the mammalian CNS. These studies address mechanisms of neural development as well as cellular responses to tissue injury. Our current projects span three major areas:
(1) Neuronal synapse formation and plasticity during development and in neuropathological conditions such as stroke and epilepsy. (2) Microglial activation and motility following brain tissue injury. (3) Astrocyte development and remodeling.
These studies employ techniques including biolistic mediated gene transfection, time-lapse fluorescence confocal imaging, and quantitative fluorescence photobleaching recovery (FRAP) in rat and mouse hippocampal tissue slices.
For more information, visit our lab web site at http://www.dailey-lab.com
Selected Publications
Ahmed R, Zha X-M, Green SH, and Dailey ME (2006) Synaptic activity and F-actin coordinately regulate CaMKIIalpha localization to dendritic postsynaptic sites in developing hippocampal slices. Molec. Cell. Neurosci. 31:37-51.
Zha X-M, Green SH, and Dailey ME (2005) Regulation of hippocampal synapse remodeling by epileptiform activity. Molec. Cell. Neurosci. 29(4):494-506.
Benediktsson AM, Schachtele SJ, Green SH, and Dailey ME (2005) Ballistic labeling and dynamic imaging of astrocytes in organotypic hippocampal slice cultures. J. Neurosci. Methods 141:41-53.
Petersen MA, and Dailey ME (2004) Diverse microglial motility behaviors during clearance of dead cells in hippocampal slices. Glia 46(2):195-206.
Marrs GS, Green SH, and Dailey ME (2001) Rapid formation and remodeling of postsynaptic densities in developing dendrites. Nature Neuroscience 4(10):1006-1013.