Inah Lee Ph.D.
inah-leeatuiowadotedu
Assistant Professor of Psychology

The ultimate research goal of my research is to uncover how the brain forms and retrieves memory. We are particularly interested in the brain functions subserving event memory or episodic memory. Episodic memory is a type of memory that entails discrete events associated with unique temporal and spatial contexts. Various structures in the medial temporal lobe (e.g., hippocampus) actively work together to retrieve relevant memories based on the representations stored in the brain. Amnesic patients who have damage in these brain structures exhibit episodic memory loss. Furthermore, other brain regions can modulate those memories dynamically. In the mammalian brain, medial temporal lobe structures have been suggested to play an essential role in forming and retrieving the episodic type of memory. My research also focuses on other brain regions (e.g., prefrontal cortex) functionally associated with the medial temporal lobe structures to fully understand how event memories are organized and utilized. Our laboratory particularly focuses on detailed neural processes (e.g., pattern completion) proposed by computational models that are presumably necessary to support mnemonic components of memories that are episodic in nature. Behavioral tasks are designed to test critical neural processes to form and retrieve episodic-like memory in rodents in combination with state-of-the-art electrophysiological and pharmacological techniques.

Selected Publications

Lee, I., Griffin, A.L., Zilli, E.A., Eichenbaum, H., and Hasselmo, M.E. (2006) Gradual translocation of spatial correlates of neuronal firing in the hippocampus towards prospective reward locations. Neuron 51:639-650.

Lee, I., Yoganarasimha, D., Rao, G., and Knierim, J. J. (2004) Comparison of population coherence of place cells in hippocampal subfields CA1 and CA3. Nature 430:456-459.

Lee, I., Rao, G., and Knierim, J. J. (2004) A double dissociation between hippocampal subfields: Differential time course of CA3 and CA1 place cells for processing changed environments. Neuron 42:803-815.

Lee, I. and Kesner, R. P. (2002) Differential contribution of NMDA receptors in hippocampal subregions to spatial working memory. Nature Neuroscience 5:162-168.