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Our laboratory studies tau protein, a microtubule associated protein that is also the primary component of the neurofibrillary tangles of Alzheimer's disease. A few years ago, we discovered that tau interacts with non-receptor src family tyrosine kinases. We are currently identifying and investigating new functions acquired by tau as a consequence of this interaction. Our hypothesis is that tau has a role in signal transduction in neurons. We are also investigating a possible role for this interaction in the neuropathogenesis of Alzheimer's disease and other age-related neurodegenerative diseases.
Selected Publications
Hall, G.F., Chu, B., Lee, G., and Yao, J. Human tau filaments induce microtubule and synapse loss in vertebrate central neurons. J. Cell Science, 113:1373-1387, 2000.
Lee G, Thangavel R, Sharma V, Litersky J, Bhaskar K, Fang S, Do L, Andreadis A, Van Hoesen G, Ksiezak-Reding H. Phosphorylation of tau by fyn: implications for Alzheimer> '> s disease. J Neurosci, 24:2304-12, 2004.
Bhaskar K, Yen S-H, Lee G. Disease related modifications in tau affect the interaction between Fyn and tau. J Biol Chem, 280:35119-25, 2005.
Lee, G. Tau and src family tyrosine kinases. Biochim Biophys Acta, 1739:323-330, 2005.