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Current research explores the neural basis of the cognitive abnormalities that characterize schizophrenia, and the cognitive and blood flow changes caused by marijuana. Both areas of research involve both behavioral cognitive assessments and structural and functional neuroimaging. We have ongoing positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) studies of schizophrenic individuals, as well normal volunteers and occasional and chronic users of marijuana.
Selected Publications
O'Leary, D.S., Andreasen, N.C., Hurtig, R.R., Hichwa, R.D., et al. A positron emission tomography study of binaurally and dichotically presented stimuli: Effects of level of language and directed attention. Brain & Language, 53:20-39, 1996.
O'Leary, D.S., Andreasen, N.C., Hurtig, R.R., Kesler, M.L. Auditory attention deficits in patients with schizophrenia. Archives of General Psychiatry, 53:633-641, 1996.
O'Leary, D.S., Andreasen, N.C., Hurtig, R.R. et. al. Auditory and visual attention assessed with PET. Human Brain Mapping, 5:422-436, 1997.
Frank, N., D.S. O¹Leary, M. Flaum, and R. Hichwa. Cerebral blood flow changes associated with Schneiderian first-rank symptoms in schizophrenia, J Neuropsychiatry and Clinical Neurosciences, 14(3):277-82, Summer, 2002.
O'Leary, D.S., R.I. Block, J.A. Koeppel, M. Flaum, S.K. Schultz, N.C. Andreasen L.L. Boles Ponto, G.L. Watkins, R.R. Hurtig, and R.D. Hichwa. Effects of smoking marijuana on brain perfusion and cognition, Neuropsychopharmacology 26(6): 802-816, 2002.
O'Leary, D.S., R.I. Block, B.M. Turner, J. Koeppel, V.A. Magnotta, L.B. Ponto, G.L. Watkins, R.D. Hichwa, and N.C. Andreasen. Marijuana alters the human cerebellar clock. NeuroReport, 11;14(8):1145-51, Jun 2003.