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Asgar Zaheer, PhD

Zaheer, Asgar
Neurology
Associate Professor
Summary statement: 

Inflammation and Neurodegeneration

Office phone: 
(319) 353-6094
Office number: 
S707
Office building: 
GH
Lab phone: 
(319) 335-8521
Lab room number: 
421
Lab building: 
MRC

My research efforts are directed towards understanding molecular mechanisms involved in the regulation of signal transduction pathways relevant to inflammatory diseases of the CNS including Multiple Sclerosis/EAE, Alzheimer's disease, and Parkinson’s disease. The recent focus of my laboratory is to investigate Glia maturation factor (GMF) signaling mechanisms involved in potentiation of CNS inflammation using cellular, and molecular techniques in primary brain cells and in GMF-knockout/ transgenic mouse models. GMF is a novel brain protein, discovered, sequenced and cloned in our laboratory at the Dept. of Neurology, University of Iowa. We have a VA Merit Review Award funded program on the role of Glia Maturation Factor in dementia, an NIH RO1-funded program on GMF in CNS inflammation, and an NIH RO1-funded program on GMF-dependent neuroinflammation and neurodegeneration . Our work embraces neurochemistry, molecular neurobiology, and neuroimmunology.

“What convinced me to attend Iowa was the Neuroscience Program. There's a deep commitment to neuroscience research at the University of Iowa, and it's reflected in the strength of the Neuroscience Program. Annually, it's ranked as one of the highest doctoral programs at the university, and the ongoing research conducted by the faculty and students is excellent. The interdisciplinary aspect of the program is tremendous for one's graduate education. There's a conflux of molecular/cellular, cognitive, systems, and behavioral research in the program and it really allows each student in the program to gain a broad spectrum of skills and knowledge in the field of neuroscience. But, the program was also attractive to me for reasons outside of the curriculum and research. From the moment I arrived on campus, the program has felt like a family. Students help each other out, and offer a great support system. And after several years of being in the program, I can undoubtedly say, Iowa was the perfect choice for me.”